TriStem has published details of its retrodiferentiation methodology as well as studies which confirm that the process creates stem cells and that these have a therapeutic benefit in peer-reviewed journals.
A review of epimorphic regeneration and retrodifferentiation
This article reviews the ability of cells in nature to reverse differentiate and regenerate tissues and organs, as well as the process of retrodifferentiation which turns human white blood cells into stem cells, which can be grown into complex tissues or body parts.
Reference: Abuljadayel IS Retrodifferentiation: From Concept to Bedside Stem Cell Therapy. Frontiers in Stem Cell and Regenerative Medicine Research 2017, 4: 3-35.
Treating patients with aplastic anaemia
Four patients were treated with a single infusion of stem cells created from their own white blood cells using TriStem’s technology. Two of the four patients with aplastic anaemia become transfusion independent for more than seven years.
Reference: Abuljadayel IS, Mohanty M and Suri RK A novel auto0logous stem cell procedure for the treatment of aplastic anaemia using reprogrammed mature adult cells: a pilot study. Indian Journal of Medical Research 2012, 135: 106-125.
A review article on the therapeutic potential for stem cells
This article explores the opportunities for treating diseases with pluripotent stem cells.
Reference: Abuljadayel IS Harnessing Pluripotency from Differentiated Cells: A Regenerative Source for Tissue-Specific Stem Cell Therapies. Current Stem Cell Research and Therapy 2006 1: 325-331.
Treating patients with beta thalassemia
Twenty one patients with beta thalassemia were treated with a single infusion of stem cells created from their own white blood cells using TriStem’s technology. Over six months after treatment, the average number of transfusions was reduced and blood iron levels reduced.
Reference: Abuljadayel IS, Quereshi, H., et al Infusion of autologous retrodifferentiated stem cells into patients with Beta-Thalassemia. TheScientificWorldJournal 2006, 6: 1278-1297.
Creation of stem cells from adults cells
This paper describes the method by which TriStem is able to create stem cells from adult blood cells.
Reference: Abuljadayel IS Induction of stem cell-like plasticity in mononuclear cells derived from unmobilised adult human peripheral blood. Current Medical Research and Opinion 2003, 19: 355-375.
Creating a new blood system in a mouse using human stem cells made by Retrodifferentiation
Stem Cells were made from Human blood cells using TriStem’s Retrodifferentiation method and infused into mice. The cells engrafted in the bone marrow and produced the full range of blood cells. When analysed, these cells had human genes in them showing that TriStem’s cells can even work in an animal model.
Reference: Abuljadayel IS, Afghan RK, McCaffrey TA et al SCID repopulating cells derived from unmobilised adult human peripheral blood. Current Medical Research and Opinion 2003 20: 87-100.