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Human Studies
 
•Infusion of Autologous Retrodifferentiated Stem Cells into Patients with Beta-Thalassemia
Beta-thalassemia is a genetic, red blood cell disorder affecting the beta-globin chain of the adult hemoglobin gene. This results in excess accumulation of unpaired alpha-chain gene products leading to reduced red blood cell life span and the development of severe anemia.
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•Harnessing Pluripotency from Differentiated Cells: A Regenerative Source for Tissue-Specific Stem Cell Therapies
Processes involving conversion of mature adult cells into undifferentiated cells have tremendous therapeutic potential in treating a variety of malignant and non-malignant disorders, including degenerative diseases.
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• SCID repopulating cells derived from unmobilised adult human peripheral blood
Severe combined immunodeficient (SCID)-repopulating cells with lymphohaematopoietic differentiation potential reside at an extremely low frequency in unmobilised adult human peripheral blood.
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• Reprogramming of Human Mature Adult Cells to Pluripotent Stem Cells by Cell Surface Contact
Nuclear transfer or cloning technology, such as the one that gave rise to Dolly the sheep, is one method of reprogramming the differentiation of  mature adult cells. Via this process, a mature adult cell is converted into a pluripotent stem cell that is capable of giving rise to all of the more than the 200 different specialised cell types that make up an organism.
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